2008年1月31日星期四
Microsoft: King of The Patent Hill
Soccer: Not for the Faint of Heart
By Constance Holden
ScienceNOW Daily News
30 January 2008
Physician Ute Wilbert-Lampen and colleagues analyzed reports of hospitalizations for heart attacks, chest pains, and arrhythmias collected by emergency medical teams on the 7 days that the German team played during the games, which were held around Germany from 9 June to 9 July. They compared the results with reports covering weeks immediately before and after the games as well as from summer months in 2003 and 2005--for a total of 4279 patients.
On the days of matches involving the German team, men in the Munich area experienced 3.26 as many cardiac events as they did during control periods. That's not too far from the fivefold increase reported after a 1994 earthquake in Los Angeles. Women were much less affected, with a cardiac event rate 1.82 times that during control periods. The games especially affected the vulnerable: 47%26#37; of the cases involved people with preexisting heart disease, compared with 29%26#37; during the control periods.
Various other studies have tried to link soccer madness with heart attacks or mortality, sometimes with conflicting results. For example, a study published in 2003 found a decrease in fatal heart attacks among Frenchmen the day France won the 1998 World Cup.
But Wilbert-Lampen and colleagues say theirs is the first study to track a precise temporal relationship between action on the field and in the chest. They found that the incidence peaked about 2 hours into a match and remained elevated for several hours afterward--indicating that the "acute trigger mechanisms" occur 1 or 2 hours before symptoms appear. Two matches in particular led to spikes in heart hospitalizations--a hard-fought victory over Argentina and an important loss to Italy--proving it's the excitement of the game and not the outcome that causes the intense stress. The team presents its findings in the 31 January issue of The New England Journal of Medicine.
Epidemiologist Diederick Grobbee of University Medical Center Utrecht in the Netherlands says the study strengthens the case for his earlier finding that the incidence of fatal heart attacks among Dutch males jumped significantly on the day of a tense soccer match. Grobbee notes that the patterns both of mortality and of the symptoms in the latest paper indicate that "rather than inducing new events [in people with no known heart trouble], the effect could be that an event that is bound to happen anyway is triggered earlier."
Mercury Reveals its Secrets
By Richard A. Kerr
ScienceNOW Daily News
30 January 2008
Mercury had its last visitor in 1975, when the Mariner 10 spacecraft returned images suggesting that lava once flowed across the surface, at least in places. But volcanism "wasn't accepted by everyone," says MESSENGER team member Louise Prockter of Johns Hopkins University's Applied Physics Laboratory in Laurel, Maryland. The new images have removed the doubt. She pointed to impact craters hundreds of kilometers across with floors so smooth that they must have been partially filled by lava. Team member Robert Strom of the University of Arizona in Tucson also found that the side of Mercury seen by Mariner 10 turns out to be more heavily cratered by impacts than the side seen for the first time by MESSENGER. That means that lava has extensively flooded the MESSENGER side. "There's been a lot of volcanic activity on Mercury," says Strom.
The moon has its volcanic flooding too--witness the dark "seas" or maria of the moon--but MESSENGER found a mercurial variation on such light-dark patterning. Caloris is a huge--1550-kilometer-wide--impact basin glimpsed by Mariner 10 but now seen in its entirety by MESSENGER. On the moon, such giant impact basins were often filled with dark lava to form maria, but Caloris has the opposite pattern. Its interior is lighter and is surrounded by a darker ring. Perhaps the Caloris impact excavated deep, lighter-colored rock and left it at the surface, says Solomon, who works at the Carnegie Institution of Washington's Department of Terrestrial Magnetism in Washington, D.C. Including smaller craters with distinctive dark rims, "we've got a variety of natural drill holes into Mercury's interior," says Solomon.
Then there's ?The Spider.? More than 50 troughs radiate from near the center of Caloris where a 40-kilometer crater has formed. Whether this inner crater has anything to do with the radiating troughs, Prockter can't say; no one has ever seen anything like the spider. One possibility is that the formation of Caloris somehow created a plume of molten rock that rose beneath the basin's center, bulging the basin floor upward and cracking the crust to form the troughs. The crater would then have been a coincidental impact.
More surprises may be in store as planetary scientists pore over the images, which are providing the first look ever at one-third of Mercury. They'll be busier still when MESSENGER returns in October for another look at Mercury on its way to entering orbit in 2011.
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2008年1月29日星期二
A Clockwork Skin Cell
By Gisela Telis
ScienceNOW Daily News
29 January 2008
To make the most of the day, humans and other animals evolved roughly 24-hour internal clocks known as circadian rhythms. A cluster of brain cells called the suprachiasmatic nucleus (SCN) runs the clock in humans, and the body's other cells have their own "slave clocks" that are synchronized to the SCN. With timekeeping outposts throughout the body, the main clock helps regulate everything from sleepiness to concentration. Buried in the brain, the SCN is not easy to study. So biochemist Steven Brown of the University of Zurich, Switzerland, and colleagues at the Free University of Berlin looked at slave clocks in skins cells, which are much more accessible.
They began by recruiting 28 extreme night owls and larks through newspaper and television ads. The team collected two small skin samples from each, and then cultured the cells in the lab and inserted the gene that makes fireflies glow into the gene that regulates the cells' clock. The result: luminous cells whose light waxes and wanes in time with their internal cycle, allowing the researchers to watch the clocks at work. To the scientists' surprise, the cells didn't desynchronize, and their behavior in the lab reflected the behavior of the humans they came from. The longest glowing cells belonged to night owls; lark skin cells glowed for shorter times, revealing a faster cycle.
"It's like a wristwatch: If it runs slow, you're late for everything; if it's too fast, you're early for everything," Brown explains. When the researchers induced the clock cycles to shift with chemicals or slight changes in temperature, they found that the cells also varied in their adaptability to change, in keeping with the volunteers' reports of varying responses to jet lag and other disruptions.
The study, published online this week in the Proceedings of the National Academy of Sciences, raises the possibility of an inexpensive and objective test of a person's "owlness" or "larkness." Such a test would be no small matter, given the prevalence of sleep disorders and the fact that many drugs, including cholesterol medications and chemotherapy, work more effectively if administered at certain points in a person's sleep/wake cycle. Pinpointing individual clock cycles could pave the way for personalized sleep and drug therapies, says Achim Kramer, a Free University chronobiologist who helped design the study.
Geneticist Paolo Sassone-Corsi of the University of California, Irvine, sees the study as an important and ingenious step. "No one had thought about taking biopsies to do this," he says. "This is a new tool, a possible new gateway to understand human rhythms."
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2010 For Next Big Windows Release?
2008年1月27日星期日
Executive Shuffle at eBay
2008年1月26日星期六
What's Next For CEP Vendors?
Can QlikTech Reveal Digg's Secrets?
2008年1月24日星期四
HP, Intel Give Old Stuff a New Shine
Motorola Forecasts Loss on Struggling Phone Biz
2008年1月23日星期三
Microsoft Hires Disney CIO
Passing the Buck on Environmental Damage
By Elizabeth Quill
ScienceNOW Daily News
22 January 2008
Sixty percent of ecological services--benefits such as clean air for breathing or timber for building--are degraded or being used unsustainably, according to the Millennium Ecosystem Assessment (Science, 1 April 2005, p. 41). However, attaching monetary value to these damages is difficult because the costs are typically ignored during economic transactions. An airline, for example, does not pay for the pollution it emits.
Despite the challenges, environmental scientist U. Thara Srinivasan of the University of California, Berkeley, and her colleagues wanted to ask an even bigger question: Who bears the costs of the damage? To simplify things, Srinivasan's team excluded areas that are hardest to monetize, such as loss of biodiversity, and instead focused on issues such as climate change, ozone layer depletion, and deforestation. First, using existing literature such as the Stern report, a U.K. study that discussed the effect of climate change on the economy (ScienceNOW, 30 October 2006), the researchers calculated the amount of damage done to the global environment between 1961 and 2000. The researchers then used existing literature to estimate how much of that damage, in dollars, was caused by high-, middle-, and low-income groups and how much these groups forgo in terms of lost ecological benefits.
The findings are striking, says Srinivasan. The highest estimates suggest humans have wrought $47 trillion worth of damage to the environment over 4 decades. (For comparison, the global gross domestic product in 2007 is estimated at $65 trillion.) Most of the blame lies with high- and middle-income nations. These countries have emitted the majority of greenhouse gases, for example, yet poor nations suffer more from the effects of the emissions, such as increased weather disturbances and increased incidence of infectious disease.
The study set the costs passed from the high- and middle-income countries to the poor countries for climate change alone at $3 trillion, a value greater than the poor countries' collective foreign debt. There are similar disparities for ozone-layer depletion and overfishing, the team reports online today in the Proceedings of the National Academy of Sciences. "To our knowledge, our study is the first to quantitatively look at where ecological footprints are falling," Srinivasan says. "Poor countries shoulder a disproportionate burden."
Srinivasan admits that there are a lot of uncertainties. The researchers had to take local estimates of annual damage--in some cases the only estimates available--and multiply those by the total area damaged and by the number of years of damage. Srinivasan says she expects the study to be controversial, but she does not intend the numbers to be taken literally. "Instead, we challenge people to think about the distribution of costs between nations," she says.
Economist Edward Barbier of the University of Wyoming, Laramie, says the effort is ambitious but unrealistic. He notes that there are simply not enough data to undertake this type of global analysis. "It's a step backward from serious attempts to bring economists and ecologists to tackle complex environmental problems, including valuing ecosystem services," he says. However, Daniel Cole, a political theorist at Indiana University School of Law in Indianapolis, says this study shows how far ecological economics has come in the past few decades. "The only thing worse than error-prone efforts to assign values to nonmarket goods may be not to make such efforts," he says.
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2008年1月20日星期日
The Secret Ingredient in Yellowstone's Travertine
By Carol Potera
ScienceNOW Daily News
18 January 2008
For Fouke, Yellowstone's travertine terraces provide a window into how mineralization occurs in coral, clam shells, and even meteorites that have struck Earth. All are composed of calcium carbonate, and because travertine in hot pools grows at a rate of 5 millimeters a day--compared with just 1 millimeter per year for coral--Yellowstone offers an ideal natural lab for observing mineralization in action, he says. Geologists have chalked up the travertine growth to inorganic processes that involve carbon dioxide forming carbonic acid that reacts with minerals and ground water. Meanwhile, microbiologists have focused on the pools' thermophiles: heat-loving microorganisms that have provided blueprints for industrial enzymes. Fouke wondered whether the geologists and microbiologists might have something in common.
To see if the thermophiles might be contributing to travertine formation, Fouke performed fluorescence microscopy on the stone, which revealed microbes encrusted in travertine at the nanoscale level. Next, Fouke's crew set up a siphonlike contraption inside a hot-spring channel to filter out microorganisms. When unfiltered water flowed into the channel, millimeter-long calcium carbonate crystals formed within hours. But when microbes were filtered out, travertine mineralization dropped by 2.5-fold.
How are the microbes helping? Fouke and proteomics expert Peter Yau of UIUC have identified several microbial proteins in samples of water collected from hot pools where mineralization readily occurs. Fouke speculates that such proteins, including heat shock proteins that microbes use to protect themselves from heat damage, could reduce the amount of energy needed for mineralization. "The words 'microbiology' and 'thermophiles' should no longer be spoken without the words 'geology' and 'water chemistry,' " Fouke told meeting attendees.
Fouke's discovery "expands the linkage between microbiology, geochemistry, and geology," says microbiologist Gill Geesey of MSU. In addition, he notes, evaluating the fine structure of calcium carbonate mineralization deposited in hydrothermal systems during different periods of Earth's evolution may offer insights into which microbes lived at which times.
Fouke says his findings could improve models used by oil and gas geologists that predict underground spaces for drilling, because microbe-induced mineral growth may close off these spaces. Moreover, the work could enhance models that predict the availability of ground water for drinking, he notes, as groundwater access could also be impeded by such growth.
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2008年1月18日星期五
PGP Updated to be a Good Citizen
2008年1月17日星期四
Apple Lightens Up
Source: Apple In addition to its svelte design, the MacBook Air incorporates features from the iPhone's touchscreen interface. The notebook's multi-touch gesture support lets users rotate and move photos and scroll through images with a finger, or zoom in or out on images with a two-fingered pinch. Other standard features include 4MB L2 processor cache, 2GB of memory, 80GB hard drive, iSight Webcam, backlit keyboard, 802.11n WiFi and Bluetooth 2.1 connectivity. Apple also will offer an optional solid-state drive, he said. But the Air lacks one component standard in most full-sized notebooks: an optical drive. The design choice hearkens back to year ago, when Jobs made made the controversial decision to cease including floppy drives on the iMac line. With even more connectivity options available in the market today, the decision not to include an optical drive figures to be less controversial -- and it helps further lighten the system's weight. "If you really want one, we have a compact Superdrive for $99 with USB connections," Jobs said. "But we don't think most users will miss having an optical drive." To compensate for the loss, user can turn to wireless and other file transfer options, including a new feature Jobs introduced called Remote Disc. The feature enables Air users to wirelessly connect to another Mac or PC on the network and access that system's optical drive. The idea is that a user can install software on his or her MacBook Air from a CD or DVD drive loaded on another computer. Next page: Movies to rent, wireless backups, Apple TV and iPhone updates
IBM's IDS to Support Mac Platform
2008年1月14日星期一
Intel Inside a White Box Blade System
IBM, Mayo Clinic Open Imaging Research Center
2008年1月12日星期六
Lenovo Cautious on Expansion in U.S. Consumer Market
2008年1月11日星期五
Cosmic Cloud on Collision Course
By Govert Schilling
ScienceNOW Daily News
11 January 2008
Many clouds of hydrogen surround the Milky Way. But astronomers didn't start spotting them until a half-century ago--after the advent of radio telescopes, which are able to detect cold, neutral hydrogen gas. The early observations were not accurate enough to determine the clouds' distances, masses, or directions of motion, however.
Now, thanks to more powerful telescopes such as the 100-meter Robert C. Byrd Green Bank Telescope in Green Bank, West Virginia, these clouds are finally getting their close-up. The first to be spotlighted in extreme detail is Smith's Cloud, named after Dutch astronomy student Gail Smith, who discovered it in 1963. Curious about the cloud's elongated shape, a team of astronomers led by Felix "Jay" Lockman of the National Radio Astronomy Observatory in Charlottesville, Virginia, took tens of thousands of radio brightness measurements. The data reveal that the cloud is just 8000 light-years away from the Milky Way's central plane, making it the closest one known. Its cometary shape is apparently due to the tidal effects of the Milky Way.
According to team member Robert Benjamin of the University of Wisconsin, Whitewater, the cloud is also closing in very fast on our galaxy. At its current speed, Smith's Cloud will collide with interstellar gas in the Milky Way's disk in less than 40 million years, says Benjamin. The crash will happen far from us, but it could still put on quite a show as the cloud's gas condenses into tens of thousands of bright, massive stars that will explode as supernovas within a couple of million years.
W. Butler Burton, a retired radio astronomer and expert on these fast-moving hydrogen clouds, says the new observations are a further step in solving the riddle of these cosmic beasts: "We never knew whether the clouds were blown out of the Milky Way, only to fall back at a later stage, or whether they are pristine intergalactic clouds falling in for the first time." Because Smith's Cloud turns out to contain almost no elements heavier than hydrogen and helium, which are relatively common in the Milky Way, it looks like a first-time visitor. Says Burton: "We might be witnessing the final stages of the formation process of our galaxy."
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IPv6 Set for Root Adoption?
2008年1月10日星期四
Hey, Wanna Buy a Subscription?
2008年1月9日星期三
The Sun Is My Guide, Quoth the Butterfly
By Elizabeth Quill
ScienceNOW Daily News
8 January 2008
Scientists believe monarchs follow the sun like a compass. But this is easier said than done. Because the sun appears to rise and fall each day, the insects must constantly adjust to its movements, lest they quickly lose their way. In 2003, Steven Reppert, a neurobiologist at the University of Massachusetts Medical School in Worcester, showed that butterflies use an internal timepiece to help them fly in the right direction (ScienceNOW, 22 May 2003).
In a pair of new studies, Reppert and his colleagues suggest that the connection between the clock and the compass relies on light-absorbing proteins called cryptochromes. First discovered in plants, cryptochromes help synchronize the internal clock--or circadian rhythm--in flies and mice (Science, 27 November 1998, p. 1628).
After assembling a database of expressed sequence tags--short DNA sequences that can be used to identify a gene expressed in a cell at a given time--Reppert and his colleagues located two families of cryptochromes in the monarch. That's unusual, Reppert notes, because other creatures studied have only one type of cryptochrome. Further molecular analysis revealed that monarchs have both a flylike cryptochrome (CRY1), which absorbs light to set the internal clock, and a mouselike cryptochrome (CRY2), which keeps the clock running. "This changes how we think molecular clocks can be put together," Reppert says. What's more, he notes, the monarch's clock may represent a timepiece that is ancestral to both flies and mice, which would imply that these creatures each lost one of the cryptochrome genes. If that's the case, studying monarch clock mechanics could provide important clues to how such timepieces evolved.
Reppert and colleagues also found that CRY2 levels oscillate daily in the part of the monarch brain responsible for following the sun like a compass. The protein might help the clock talk to the compass and therefore give the butterflies their bearings during the long journey. The team presents the database findings tomorrow in PLoS ONE and describes the role of cryptochromes in the butterfly clock today in PLoS Biology.
Gene Robinson, a neuroscientist at the University of Illinois, Urbana-Champaign, says the study provides a basis for the proposal that cryptochrome connects the circadian clock to the sun compass. Still, Orley ?Chip? Taylor Jr., an insect ecologist at the University of Kansas, Lawrence, says the work does little to explain navigation. To make it to Mexico, monarchs coming from New York, Texas, or Iowa, for example, would have to follow different bearings and begin their journeys at different times. This is hard to reconcile with a specieswide clock, he notes. "We are a long way from understanding that," Taylor says.
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Rogue Black Holes May Abound in Milky Way
By Govert Schilling
ScienceNOW Daily News
9 January 2008
Black holes--regions of space where gravity is so strong that even light can't escape--come in various sizes. The smaller ones are a few times more massive than the sun and form when massive stars burn out and implode. In contrast, supermassive black holes reside in the cores of galaxies and can be up to billions of solar masses. And astronomers have circumstantial evidence for the existence of a third class: intermediate-mass black holes that weigh in at a few hundred to a few thousand suns. They might form within dense, spherical swarms of hundreds of thousands of stars known as globular clusters, although no one is sure how (ScienceNOW, 17 September 2002). If such intermediate-mass black holes do exist, then a new analysis suggests that many of them are spit out by the clusters and end up roaming through space alone, Kelly Holley-Bockelmann of Vanderbilt University in Nashville, Tennessee, reported at the meeting.
Why would a globular cluster eject its intermediate-mass black hole? The answer, according to Holley-Bockelmann and her colleagues, lies in mergers with smaller, stellar-mass black holes that would also form in the cluster and slowly sink to its core. According to general relativity, the merging of the two black holes produces a burst of gravitational waves, which are literally expanding ripples in spacetime itself. If the merger is off-center, or if the two black holes spin at different speeds or in different directions, the gravitational waves emerge asymmetrically. The asymmetric waves would act like a rocket on the combined black hole, flinging it out of the cluster with a velocity of thousands of kilometers per second.
As the Milky Way contains some 200 globular clusters, hundreds of rogue black holes may be crisscrossing our galaxy, says Holley-Bockelmann. Spotting them may be difficult, however. They would be visible only if they encounter interstellar gas clouds to feed on, in which case they would heat some of the gas and cause it to emit x-rays. Alternatively, says Holley-Bockelmann, a roaming hole might reveal itself if it passes in front of a more distant star. The black hole's gravity would then distort the image of the background star in telltale ways in a process called gravitational lensing (ScienceNOW, 6 October 2006).
"Learning more about intermediate-mass black holes and their possible fates is very interesting" because so little is known about them, says theoretical astrophysicist J. Craig Wheeler of the University of Texas, Austin. He notes that many other processes in the Milky Way may also send smaller black holes drifting through space: "There might be 100 million stellar-mass black holes out there."
So should we worry about a hefty intermediate-mass black hole coming our way? No, says Holley-Bockelmann, there are too few of them. "The most dangerous effect I can think of is a rogue black hole stirring up our solar system's Oort cloud of comets, which would send huge numbers of comets on a potential collision course with Earth. But the chance of that happening is only one in a quadrillion or so. There's no need to build black-hole shelters."
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MicroRNAs Keep Tumors in Place
By Jennifer Couzin
ScienceNOW Daily News
9 January 2008
Metastasis is thought to occur for a host of reasons. Certain genes may be turned on or off in tumors, causing cells to jump ship; and some environments in the body are more hospitable to wandering cancer cells. Recently, scientists have begun to consider the role of microRNAs, which appear to be expressed at very low levels in tumors. That's led to speculation that when turned on, microRNAs can suppress tumors.
Joan Massagu%26eacute;, a cancer biologist at Memorial Sloan-Kettering Cancer Center in New York City, cast a wide net for disappearing microRNAs in breast cancers. He and his colleagues examined microRNA expression in cell lines from patients with aggressive breast cancer that had spread to bones or the lungs. They came up with six microRNAs whose expression was vanishingly low compared to normal tissue. The researchers injected mice with metastatic cells from a patient with breast cancer. When lesions formed in the bones or lungs of the animals, the team found very low expression of three of the six microRNAs.
Massagu%26eacute; and his colleagues also studied 368 banked tumor samples from breast cancer patients and looked at expression of the genes that are suppressed by the six key microRNAs; when gene expression is high, the microRNAs aren't active, and when it's low, they are. The researchers found that patients whose tumors expressed the genes had about a 50%26#37; chance of being alive and not having metastatic cancer after 10 years. Among those patients that were negative for all six genes--in other words, those whose microRNA expression was high and damping down gene expression--the number was about 75%26#37;, the team reports in the 10 January issue of Nature.
The team also investigated the impact of restoring expression of microRNAs in cancer cells injected into mice. Boosting expression of three of the six microRNAs before injecting the cancer cells dramatically reduced lung and bone metastases, although the mice still developed them eventually. "That was a very clean experiment," says Massagu%26eacute;. But "it's a far cry" from treating patients.
Laura van 't Veer, a molecular biologist at the Netherlands Cancer Institute in Amsterdam, agrees that clinical applications are far off, but she says the findings are promising. At the very least, microRNAs "may represent especially good indicators of metastasis" and could be used diagnostically, says Robert Weinberg, a cancer biologist at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, whose group last year described a microRNA that plays a role in breast cancer metastasis (ScienceNOW, 26 September 2007). Massagu%26eacute; is now studying whether the microRNAs he came up with help prevent metastasis in other cancers.
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Study Revises Iraq's Death Toll
By John Bohannon
ScienceNOW Daily News
9 January 2008
Between 2006 and 2007, Iraqi surveyors led by WHO epidemiologist Mohammed Ali knocked on the doors of 9345 Iraqi homes. The addresses were chosen randomly within about 1000 neighborhoods and villages across the country. Besides basic information about the household, interviewers asked about illnesses and death among occupants since the beginning of 2002.
This survey, like the earlier Lancet study, found that violence became a leading cause of death in Iraq after the March 2003 invasion. The WHO team used the same method of extrapolation to calculate total death rate as the Lancet group did, but their average estimate of violent deaths is 151,000--far lower than the Lancet's 601,000. When the WHO surveyors were assigned a cluster of households in a neighborhood deemed too dangerous to visit, they used data from Iraq Body Count, a London-based database of media-reported Iraqi casualties whose numbers are considered a floor. "Some homes could not be visited because of high levels of insecurity," says Iraqi health minister Salih Mahdi Motlab Al-Hasanawi, who was not an author. "Nonetheless, the survey results indicate a massive death toll since the beginning of the conflict."
Researchers say any attempts to calculate death tolls during a war will have limitations, but they are impressed by the new study. "There are inherent biases in a household survey like this one," says John Brownstein, an epidemiologist at Harvard Medical School in Boston, particularly when the total population size is not well-known. "But their approach was rigorous, and they accounted for all reasonable criticisms."
Brownstein declined to comment on the Lancet study, noting only that the WHO study's sample size--five times larger than that of the Lancet study--makes it "more robust, all things being equal." But some researchers are not as forgiving. "This study is a slaughter of the Lancet study," says Michael Spagat, an economist at Royal Holloway, University of London, in the U.K. "Serious problems with that study have been evident for a long time, but this confirms it."